Key result
Fever unmasks Brugada type 1 pattern, prompting ICD placement after ajmaline-induced ventricular fibrillation.
Why the study?
Brugada-type ECG can be unmasked and induced by several circumstances including febrile states, which may increase sudden cardiac death risk despite a structurally normal heart.
Case Report (n=1)
A febrile state can unmask a Brugada type 1 ECG pattern, identifying patients at risk for sudden cardiac death who may require ICD implantation.
Febrile syncope evaluation should consider Brugada unmasking; hypothesis-generating and should not yet change practice.
Brugada syndrome is a genetic disease characterized by persistent or transient ST elevation in the right precordial electrocardiogram (ECG) leads with or without right bundle branch block. It represents an increased risk for sudden cardiac death despite a structurally normal heart. Brugada-type ECG can be unmasked and induced by several circumstances. We report on a 24-year-old male patient who experienced a syncopal episode and manifested Brugada type 1 ECG during a febrile state. His ECG changed to normal after treatment of fever. A single-chamber ICD was implanted to the patient because of syncope, fever-induced type I Brugada ECG pattern, and ventricular fibrillation during ajmaline challenge.
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Kıvanç Yalın (2012) conducted a case report in Brugada syndrome (n=1). Febrile state was evaluated on Brugada type 1 ECG manifestation. A febrile state unmasked a Brugada type 1 ECG pattern in a 24-year-old male following a syncopal episode, leading to ICD implantation after ventricular fibrillation during ajmaline challenge.
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