Key result
Brugada syndrome and early repolarization syndrome share many clinical characteristics and underlying cellular electrophysiologic mechanisms related to the electrocardiographic J wave.
This review highlights the shared clinical characteristics and underlying cellular electrophysiologic mechanisms of Brugada syndrome and early repolarization syndrome.
Supports spectrum concept for J-wave syndromes in risk assessment; leaves open need for prospective validation of unified management.
Brugada syndrome (BS) and early repolarization syndrome (ERS) are newly introduced electrical disorders responsible for ventricular fibrillation (VF) and sudden cardiac death in patients with structurally normal hearts. The electrocardiographic J wave, a hallmark of these two syndromes, plays a critical role in the pathophysiology of malignant ventricular tachyarrhythmias. BS and ERS share many clinical characteristics, including male preponderance, circadian distribution of VF episodes, prevalence of concomitant atrial tachyarrhythmias, dynamic behavior of J waves, and response to therapeutic managements. In this review, we compare the key clinical manifestations of BS and ERS with their underlying cellular electrophysiologic mechanisms.
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Gi‐Byoung Nam (2013) conducted a review in Brugada syndrome and early repolarization syndrome. Brugada syndrome and early repolarization syndrome share many clinical characteristics and underlying cellular electrophysiologic mechanisms related to the electrocardiographic J wave.
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