Key result
Review synthesizes clinical characteristics, risk stratifiers, and mechanisms of Brugada and early repolarization syndromes.
This review summarizes the clinical characteristics, risk stratification, and underlying mechanisms of J wave syndromes, including Brugada and early repolarization syndromes.
Synthesizes J-wave syndrome features for clinicians; leaves open prospective validation of integrated risk models.
The J wave syndromes, including the Brugada (BrS) and early repolarization (ERS) syndromes, are characterized by the manifestation of prominent J waves in the electrocardiogram appearing as an ST segment elevation and the development of life-threatening cardiac arrhythmias. BrS and ERS differ with respect to the magnitude and lead location of abnormal J waves and are thought to represent a continuous spectrum of phenotypic expression termed J wave syndromes. Despite over 25 years of intensive research, risk stratification and the approach to therapy of these two inherited cardiac arrhythmia syndromes are still rapidly evolving. Our objective in this review is to provide an integrated synopsis of the clinical characteristics, risk stratifiers, as well as the molecular, ionic, cellular, and genetic mechanisms underlying these two syndromes that have captured the interest and attention of the cardiology community over the past two decades.
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Diego et al. (2018) conducted a review in J wave syndromes (Brugada syndrome and early repolarization syndrome). This review provides an integrated synopsis of the clinical characteristics, risk stratifiers, and mechanisms underlying Brugada and early repolarization syndromes.
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