Key result
J wave syndrome spans benign early repolarization to malignant Brugada syndrome requiring targeted ICD therapy.
Why the study?
J wave syndrome encompasses a clinical spectrum from benign early repolarization patterns to malignant ventricular arrhythmias, but its definitions, risk stratification, and therapeutic options require detailed discussion.
Supports cautious risk stratification for J-wave patterns; extends spectrum understanding but prospective validation needed before practice change.
J wave syndrome is an electrical disease of the heart due to pathologic early repolarization. It encompasses a clinical spectrum from aborted sudden cardiac death due to ventricular arrhythmia (VA) usually in young affected patients to self-terminating ventricular ectopies, and finally, asymptomatic relatives of probands detected during electrocardiography acquisition (early repolarization pattern). This syndrome consists of 2 phenotypes, early repolarization and Brugada syndrome. Herein, we first describe 2 patients with early repolarization and Brugada syndrome, then, discuss their definition, epidemiology, genetics, cellular mechanism, diagnosis, risk stratification, and finally, therapeutic challenges and options one by one in detail.
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Sherafati et al. (2021) conducted a review in J wave syndrome (Early repolarization and Brugada syndrome) (n=2). J wave syndrome encompasses a clinical spectrum from benign early repolarization to malignant Brugada syndrome, requiring careful risk stratification and management such as ICD implantation in high-risk patients.
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