Key result
Each myosin VI head binds two calmodulins, with one binding to a unique insertion between the converter region and IQ motif that requires calcium occupancy of its C-terminal lobe.
Population
Myosin VI protein (truncations)
Design
Preclinical
Authors
Loading...
Findings remain preclinical and should not change practice; extends structural model of myosin VI regulation.
The unique insert in myosin VI acts as a structural binding site for a second calmodulin molecule, which likely repositions the lever arm to enable reverse direction motility on actin.
Bahloul et al. (2004) studied this question. Each myosin VI head binds two calmodulins, with one binding to a unique insertion between the converter region and IQ motif that requires calcium occupancy of its C-terminal lobe.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: