Key result
Pulmonary endarterectomy for CTEPH is linked to near-normal long-term quality of life in ~74% of patients.
Why the study?
Little is known about long-term quality of life and functional status after pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension.
Does pulmonary endarterectomy improve long-term quality of life and functional status in patients with chronic thromboembolic pulmonary hypertension?
Cohort (n=110)
No
Does pulmonary endarterectomy improve long-term quality of life and functional status in patients with chronic thromboembolic pulmonary hypertension?
Patients undergoing pulmonary endarterectomy for chronic thromboembolic pulmonary hypertension achieve satisfactory long-term quality of life and high functional status, approaching that of a reference population.
Supports durable functional recovery after pulmonary endarterectomy in CTEPH; leaves open need for randomized confirmation.
Little is known about long-term quality of life (QOL) and functional status after pulmonary endarterectomy (PEA) for chronic thromboembolic pulmonary hypertension (CTEPH). We investigated QOL and functional status late after PEA. All patients who underwent PEA for CTEPH 1993-2020 at one Swedish center were included. Baseline characteristics and data from right heart catheterization, 6-min walk test, and Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR) were obtained from patient charts and national registers. The RAND 36-Item Health Survey was sent by post, and Karnofsky Performance Status (KPS) was evaluated by telephone. A total of 110 patients were included. The survey was completed by 49/66 (74%) patients who were alive in 2020. In all domains except for bodily pain, QOL was slightly lower than that of an age-matched reference population. The KPS score was obtained from 42/49 (86%) patients; of these, 31 patients (74%) had a KPS score of ≥80% (able to carry on normal activity). All 42 patients were able to live at home and care for personal needs. The median postoperative CAMPHOR scores were: 4 for symptoms, 4 for activity, and 2.5 for QOL. We observed that QOL after PEA approached the expected QOL in a reference population and that CAMPHOR scores were comparable to those of a large UK cohort after PEA. Functional status improved when assessed late after PEA. Three-quarters of the study population were able to conduct normal activities at late follow-up. Our findings suggest that many patients enjoy satisfactory QOL and high functional status late after PEA.
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Kallonen et al. (2023) conducted a cohort in Chronic thromboembolic pulmonary hypertension (CTEPH) (n=110). Pulmonary endarterectomy (PEA) vs. Age-matched reference population was evaluated on Quality of life (QOL) and functional status. Pulmonary endarterectomy for CTEPH resulted in satisfactory long-term quality of life approaching an age-matched reference population, with 74% of assessed patients achieving a KPS score ≥80%.
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