Key result
~47% of measured CV-related proteins are linked to at least one subclinical CV trait.
Why the study?
Understanding molecular processes in the early phase of atherosclerotic cardiovascular disease is critical for early prediction and intervention measures.
Do specific cardiovascular-disease-related proteins associate with subclinical cardiovascular traits in an elderly population?
Observational (n=2,014)
No
Do specific cardiovascular-disease-related proteins associate with subclinical cardiovascular traits in an elderly population?
This study extends the catalogue of proteome biomarkers involved in early stages of cardiovascular disease, providing potential targets for early risk prediction or intervention strategies.
Identifies protein links to subclinical traits in the elderly; extends the biomarker catalogue but leaves open causality and clinical utility.
BACKGROUND AND AIMS: Understanding molecular processes of the early phase of atherosclerotic cardiovascular disease conditions is of utmost importance for early prediction and intervention measures. METHODS: We measured 92 cardiovascular-disease-related proteins (Olink, Cardiovascular III) in 2024 elderly participants of the population-based LIFE-Adult study. We analysed the impact of 27 covariables on these proteins including blood counts, cardiovascular risk factors and life-style-related parameters. We also analysed protein associations with 13 subclinical cardiovascular traits comprising carotid intima media thickness, plaque burden, three modes of Vicorder-based pulse-wave velocities, ankle-brachial index and ECLIA-based N-terminal prohormone of brain natriuretic peptide (NT-proBNP). RESULTS: Estimated glomerular filtration rate, triglycerides and sex where the most relevant covariables explaining more than 1 % variance of 49, 22 and 20 proteins, respectively. A total of 43 proteins were significantly associated with at least one of the analysed subclinical cardiovascular traits. NT-pro-BNP, brachial-ankle pulse-wave velocity (baPWV) and parameters of carotid plaque burden accounted for the largest number of associations. Association overlaps were relatively sparse. Only growth/differentiation factor 15, low density lipoprotein receptor and interleukin-1 receptor type 2 are associated with these three different cardiovascular traits. We confirmed several literature findings and found yet unreported associations for carotid plaque presence (von-Willebrand factor, galectin 4), carotid intima-media thickness (carboxypeptidase A1 andB1), baPWV (cathepsin D) and NT-proBNP (cathepsin Z, low density lipoprotein receptor, neurogenic locus homolog protein 3, trem-like transcript 2). Sex-interaction effects were observed, e.g. for spondin-1 and growth/differentiation factor 15 likely regulated by androgen response elements. CONCLUSIONS: We extend the catalogue of proteome biomarkers possibly involved in early stages of cardiovascular disease pathologies providing targets for early risk prediction or intervention strategies.
No takes yet. Share an insight, caveat, or question.
Garcia et al. (2024) conducted an observational in Subclinical cardiovascular traits (n=2,014). Cardiovascular-disease-related proteins (Olink CVD III panel) was evaluated on Association of proteins with subclinical cardiovascular traits. Among 2014 participants, 43 of 92 measured cardiovascular-disease-related proteins were significantly associated with at least one subclinical cardiovascular trait.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: