March 1, 2006Journal of Cardiovascular Pharmacology and TherapeuticsOpen Access

Subcellular Remodeling as a Viable Target for the Treatment of Congestive Heart Failure

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Population

Patients with different types of congestive heart failure (CHF) and various experimental models of CHF

Design

Review

Authors

NDNaranjan S. DhallaElectrophysiology MDMelissa R. DentSt. Boniface Hospital PTParamjit S. TappiaSt. Boniface Hospital

Discussion

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Implication

ACE inhibitors may target subcellular remodeling in HF; hypothesis-generating and requires prospective trials before practice change.

Structured PICO

Population

Patients with different types of congestive heart failure (CHF) and various experimental models of CHF

Intervention

Angiotensin-converting enzyme inhibitors and angiotensin receptor antagonists

Outcome

Subcellular remodeling (changes in sarcolemma, sarcoplasmic reticulum, and myofibril enzyme activities, protein contents, and gene expression) and cardiac functionsurrogate

Subcellular remodeling, characterized by defective organelle function, is a key mechanism in the transition from cardiac hypertrophy to heart failure and represents a viable therapeutic target.

Cite This Study

Dhalla et al. (2006) studied this question.

synapsesocial.com/papers/6a0e8fdfa0467873efc842d0 https://doi.org/10.1177/107424840601100103

Topics

Heart failure HFrEF treatment

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Subcellular Remodeling as a Viable Target for the Treatment of Congestive Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Subcellular Remodeling as a Viable Target for the Treatment of Congestive Heart Failure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider