Population
Isolated rat cardiomyocytes plated on laminin-coated coverslips
Comparison
5-ms biphasic field-stimulation pulse with… vs 0.5-ms current injection through high-resistance…
Design
Preclinical
Authors
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Alerts to mechanistic artifacts with field stimulation in vitro; leaves open applicability to intact myocardium.
Field stimulation of isolated cardiomyocytes triggers contraction via a different mechanism (L-type Ca2+ current and reverse mode Na+/Ca2+ exchange) than physiological action potentials, which prolongs time to peak contraction.
Bøkenes et al. (2005) studied this question.
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