Key result
Pacing-induced SVT cardiomyopathy in pigs significantly reduced LV fractional shortening (12% vs 28%, p<0.05) and isolated myocyte contractile performance compared to controls.
Population
12 pigs (6 with pacing-induced SVT cardiomyopathy and 6 control pigs), including isolated myocytes
Comparison
Pacing-induced supraventricular tachycardia vs Unpaced control pigs
Design
Preclinical
Follow-up
3 weeks
Authors
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Supports primary myocyte defects in tachycardia cardiomyopathy; hypothesis-generating for human translation.
Absolute Event Rate: 12% vs 28%
p-value: p=<0.05
Tachycardia-induced cardiomyopathy is associated with a primary defect in isolated myocyte contractile performance, cytoarchitecture abnormalities, and blunted calcium responsiveness.
Spinale et al. (1992) studied Tachycardia-induced cardiomyopathy (n=12). Pacing-induced SVT vs. Control was evaluated on LV fractional shortening (p=<0.05). Pacing-induced SVT cardiomyopathy in pigs significantly reduced LV fractional shortening (12% vs 28%, p<0.05) and isolated myocyte contractile performance compared to controls.
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