What does this research mean for the field?

Termination of supraventricular tachycardia normalizes systolic function but is associated with the development of left ventricular hypertrophy and persistent diastolic dysfunction. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate changes in left ventricular volume, mass, and systolic versus diastolic performance during the development and recovery phases of supraventricular tachycardia-induced cardiomyopathy.

February 1, 1991CirculationOpen Access

Changes in left ventricular volume, mass, and function during the development and regression of supraventricular tachycardia-induced cardiomyopathy. Disparity between recovery of systolic versus diastolic function.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Supraventricular tachycardia-induced cardiomyopathy (n=27). Intervention: Rapid left atrial pacing and subsequent termination vs. Sham-operated controls. Primary outcome: Left ventricular volume, mass, systolic and diastolic function.

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Key result

Termination of supraventricular tachycardia in pigs normalized systolic function but was associated with the development of LV hypertrophy and persistent diastolic dysfunction (tau 49 +/- 12 msec, p<0.05 vs control).

Why the study?

Does termination of supraventricular tachycardia improve left ventricular volume, mass, and function in a pig model of tachycardia-induced cardiomyopathy?

Population

Pigs (n=27 total: 8 in SVT group, 9 in PSVT group, 10 in CTR group)

Comparison

Rapid left atrial pacing for 3 weeks, or rapid… vs Sham-operated controls (CTR)

Design

Preclinical

Follow-up

3 weeks for SVT group, 7 weeks for PSVT group

Authors

MTMasaaki TomitaYamagata Prefectural Institute of Public Health FSFrancis G. SpinaleMedical University of South Carolina FCFred A. CrawfordMedical University of South Carolina

Discussion

Member takes

Implication

May indicate persistent diastolic impairment despite systolic recovery post-SVT termination in pigs; leaves open clinical relevance in human tachycardia cardiomyopathy.

Key Points

To investigate changes in left ventricular volume, mass, and systolic versus diastolic performance during the development and recovery phases of supraventricular tachycardia-induced cardiomyopathy.
Assigned 27 pigs to 3 weeks of rapid left atrial pacing at 240 beats/min (SVT, n = 8), 3 weeks of pacing followed by a 4-week recovery period (PSVT, n = 9), or sham control (CTR, n = 10).
Evaluated hemodynamics, systolic indices (fractional shortening, peak dP/dt, peak ejection rate), and diastolic indices (time constant tau, chamber stiffness Kc, myocardial stiffness Km) using simultaneous echocardiography and catheterization.
Active tachycardia (SVT) induced LV dilation (end-diastolic dimension 4.9 ± 0.5 cm vs 3.5 ± 0.4 cm in CTR, p < 0.05), systolic pump dysfunction (fractional shortening 13 ± 5% vs 30 ± 4% in CTR, p < 0.05), and impaired relaxation (tau 51 ± 13 msec vs 36 ± 3 msec in CTR, p < 0.05) without altering LV mass.
Following tachycardia termination (PSVT), systolic function normalized (fractional shortening 31 ± 5%), but animals developed LV hypertrophy (LV weight-to-body weight ratio 3.48 ± 0.5 g/kg vs 2.58 ± 0.3 g/kg in CTR, p < 0.05) alongside persistent diastolic abnormalities (tau 49 ± 12 msec, Kc 7.4 ± 1.2, Km 13.9 ± 9.7; all p < 0.05 vs CTR).

Structured PICO

Does termination of supraventricular tachycardia improve left ventricular volume, mass, and function in a pig model of tachycardia-induced cardiomyopathy?

Population

Pigs (n=27 total: 8 in SVT group, 9 in PSVT group, 10 in CTR group)

Intervention

Rapid left atrial pacing (240 beats/min) for 3 weeks (SVT group), or rapid pacing for 3 weeks followed by termination and a 4-week recovery period (PSVT group)

Comparator

Sham-operated controls (CTR)

Outcome

Left ventricular volume, mass, systolic function (fractional shortening, peak ejection rate, maximum rate of pressure development), and diastolic function (tau, peak early diastolic filling rate, chamber stiffness constant, myocardial stiffness constant)surrogate

In a pig model of SVT-induced cardiomyopathy, termination of tachycardia normalizes systolic function but is associated with the development of LV hypertrophy and persistent diastolic dysfunction.

Cite This Study

Tomita et al. (1991) studied Supraventricular tachycardia-induced cardiomyopathy (n=27). Rapid left atrial pacing and subsequent termination vs. Sham-operated controls was evaluated on Left ventricular volume, mass, systolic and diastolic function. Termination of supraventricular tachycardia in pigs normalized systolic function but was associated with the development of LV hypertrophy and persistent diastolic dysfunction (tau 49 +/- 12 msec, p<0.05 vs control).

synapsesocial.com/papers/6a15305479ff98d0de4e3869 https://doi.org/10.1161/01.cir.83.2.635

Topics

Echocardiography

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Implication

May indicate persistent diastolic impairment despite systolic recovery post-SVT termination in pigs; leaves open clinical relevance in human tachycardia cardiomyopathy.

Changes in left ventricular volume, mass, and function during the development and regression of supraventricular tachycardia-induced cardiomyopathy. Disparity between recovery of systolic versus diastolic function.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Changes in left ventricular volume, mass, and function during the development and regression of supraventricular tachycardia-induced cardiomyopathy. Disparity between recovery of systolic versus diastolic function.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider