Key result
A video-based device successfully measured overall shortening in guinea pig and rabbit cardiac myocytes, which shortened an average of 8.1% and 9.0% of cell length, respectively.
The described video-based motion detector provides an inexpensive, easy-to-use method with high spatial and adequate temporal resolution for measuring shortening in isolated cardiac myocytes.
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Enables cost-effective myocyte studies in animal models; leaves open validation and translation to human cardiomyocytes.
Steadman et al. (1988) studied isolated cardiac myocytes. video-based motion detector was evaluated on extent and rate of shortening. A video-based device successfully measured overall shortening in guinea pig and rabbit cardiac myocytes, which shortened an average of 8.1% and 9.0% of cell length, respectively.
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