Population
Rat hepatocyte cultures in conditions resembling the fed situation (absence of extracellular fatty acids)
Comparison
Tumor necrosis factor-alpha at 5, 20, or 100 ng/mL vs Untreated cells (baseline levels)
Design
Preclinical
Follow-up
up to 16 hours
Authors
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Hypothesis-generating for TNF-alpha effects on VLDL in inflammation; does not yet inform clinical lipid management.
TNF-alpha directly upregulates apoB mRNA expression and transiently increases VLDL particle secretion in rat hepatocytes, but does not affect VLDL triglyceride secretion in the absence of extracellular fatty acids.
Bartolomé et al. (2007) studied this question.
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