Key result
Administration of human TNF to rats increased serum triglycerides but produced limited and tissue-specific decreases in lipoprotein lipase activity, which cannot fully account for the hypertriglyceridemia.
The limited effects of TNF on LPL in vivo cannot fully explain the rapid and sustained increase in serum triglycerides observed after TNF administration.
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TNF-induced hypertriglyceridemia in rats is incompletely explained by LPL changes; hypothesis-generating for alternative mechanisms in inflammatory dyslipidemia.
Grünfeld et al. (1989) studied this question. Human tumor necrosis factor (TNF) was evaluated on Lipoprotein lipase (LPL) activity and serum triglycerides. Administration of human TNF to rats increased serum triglycerides but produced limited and tissue-specific decreases in lipoprotein lipase activity, which cannot fully account for the hypertriglyceridemia.
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