Microrna and Chronic Heart Failure: Prospects for Clinical Application

Highlights This review is focused on up-to-date studies investigating possibility of using microRNAs as diagnostic biomarkers, predictors of unfavorable outcome and potential therapy for chronic heart failure. Abstract Chronic heart failure is one of the leading causes of disability and mortality in cardiology patients. Despite significant achievements of modern medicine, the incidence of chronic heart failure and its hospitalization rate increase drastically. Therefore, the search for highly sensitive, specific, reliable and standardized biomarkers for the earliest diagnosis and prevention of chronic heart failure complications seems relevant. MicroRNAs (miRNA) are considered as promising novel genetic biomarkers for purposes of diagnosis and prognosis of cardiovascular diseases. This article provides an overview of data from experimental and clinical studies discussing the possibility of using miRNA for early diagnosis and determining prognosis of chronic heart failure, as well as a possibility of miRNA therapeutic application.