Key result
Helical ventricular myocardial band mechanics inform pathophysiology and novel treatments for HF, dyssynchrony, and valvar disease.
Understanding the form/function interactions within the helical ventricular myocardial band is essential for comprehending cardiac diseases and planning novel treatments for conditions like heart failure, dyssynchrony, and valvular insufficiency.
May guide anatomy-informed therapies in HF and dyssynchrony; leaves open prospective validation before clinical adoption.
Normal cardiac function of the left and right ventricles, together with the septum, is related to form/function interactions within the helical ventricular myocardial band. This knowledge is a prerequisite to understanding form/function interactions in diseases and for planning new treatments. Topics discussed include congestive heart failure in dilated hearts of ischaemic, valvar or nonischaemic origin as well as diastolic dysfunction. Similar thinking underlies novel treatments for dyssynchrony in pacing, together with focusing upon varying global left or right ventricular anatomy to correct mitral and tricuspid insufficiency caused by tethering of the leaflets. The septum is the lion of the right ventricle and insight is provided into offsetting septal damage during cardiac surgery, rebuilding its anatomical structure in post-tetralogy pulmonary insufficiency, as well as rectifying its dysfunction by decompression in patients with a left ventricular assist device.
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Buckberg et al. (2014) conducted a review in Ventricular structure-function relations in health and disease. Understanding form/function interactions within the helical ventricular myocardial band provides insight into the pathophysiology and novel treatments for heart failure, dyssynchrony, and valvar disease.
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