Key result
Activation of the ACE2/Ang-(1-7)/MasR axis offers potential benefits in the pathophysiology and treatment of diabetes and its cardiovascular complications by opposing the effects of AngII.
Why the study?
Does ACE2/Ang-(1-7)/MasR axis activation prevent or improve diabetic cardiovascular complications?
Population
Patients with diabetes and animal models of diabetes
Design
Review
Authors
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May inform targeted therapies for diabetic CV complications; leaves open need for randomized trials before clinical adoption.
Does ACE2/Ang-(1-7)/MasR axis activation prevent or improve diabetic cardiovascular complications?
This review highlights the protective role of the ACE2/Ang-(1-7)/MasR axis against diabetic cardiovascular complications and systolic dysfunction.
Patel et al. (2013) conducted a review in Diabetic cardiovascular complications. ACE2/Ang-(1-7)/MasR axis activation was evaluated. Activation of the ACE2/Ang-(1-7)/MasR axis offers potential benefits in the pathophysiology and treatment of diabetes and its cardiovascular complications by opposing the effects of AngII.