Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
July 29, 2013IUBMB LifeOpen Access

Angiotensin converting enzyme 2: A new important player in the regulation of glycemia

View Full Paper
Ask AI
Bookmark
Share

Key result

Restoration of the ACE2/Ang-(1-7)/MasR axis appears to be a promising protective therapeutic strategy for improving glycemia in type 2 diabetes mellitus.

Why the study?

Does restoration of ACE2 improve glycemia in type 2 diabetes mellitus?

Population

Type 2 diabetes mellitus (T2DM) patients and preclinical models (db/db and Ang-II-infused mice)

Design

Review

Authors

KCKavaljit H. ChhabraUniversity of KentuckyHCHarshita ChodavarapuCedars-Sinai Medical CenterELEric LazartiguesGeneral Cardiology

Discussion

Loading...

Member takes

Implication

Supports RAS attenuation for glycemic control in T2DM; leaves open clinical utility pending randomized trials.

Structured PICO

Does restoration of ACE2 improve glycemia in type 2 diabetes mellitus?

P
Population
Type 2 diabetes mellitus (T2DM) patients and preclinical models (db/db and Ang-II-infused mice)
I
Intervention
Restoration of ACE2 levels / ACE2/Ang-(1-7)/MasR axis activation
O
Outcome
Improvement in glycemia and insulin sensitivitysurrogate

Restoration of ACE2 levels represents a promising therapeutic strategy for managing glycemia in type 2 diabetes by counteracting the negative effects of Ang-II and enhancing Ang-(1-7)/MasR signaling.

Cite This Study

Chhabra et al. (2013) conducted a review in Type 2 diabetes mellitus (T2DM). ACE2/Ang-(1-7)/MasR axis restoration was evaluated. Restoration of the ACE2/Ang-(1-7)/MasR axis appears to be a promising protective therapeutic strategy for improving glycemia in type 2 diabetes mellitus.

synapsesocial.com/papers/6a6bb9ef34b735385cb3ce05https://doi.org/10.1002/iub.1190
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.1997 · 426 citations
  2. 2Evidence for the Existence of a Functional Cardiac Renin-Angiotensin System in Humans1996 · 82 citations
  3. 3Localization and differential regulation of angiotensinogen mRNA expression in the vessel wall.1991 · 137 citations
  4. 4Angiotensin-Converting Enzyme: Vascular Endothelial Localization1976 · 635 citations
  5. 5Angiotensin-Converting Enzyme 2 Suppresses Pathological Hypertrophy, Myocardial Fibrosis, and Cardiac Dysfunction2010 · 461 citations