Key result
In human atrial tissue, chymase is the primary enzyme responsible for generating Angiotensin II from Angiotensin-(1-12), accounting for 65% of Ang II formation compared to only 2% by ACE.
Why the study?
Does chymase mediate the generation of Angiotensin II from Angiotensin-(1-12) in human atrial tissue?
Does chymase mediate the generation of Angiotensin II from Angiotensin-(1-12) in human atrial tissue?
Absolute Event Rate: 65% vs 2%
p-value: p=<0.05
This study demonstrates that cardiac chymase, rather than ACE, plays a dominant role in generating Angiotensin II from Angiotensin-(1-12) in human atrial tissue.
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Chymase inhibition merits exploration in atrial disease; leaves open in vivo relevance and clinical translation.
Ahmad et al. (2011) studied Atrial fibrillation (n=9). Chymase inhibition (chymostatin) vs. ACE inhibition (lisinopril) was evaluated on Angiotensin II formation from 125I-Ang-(1-12) (p=<0.05). In human atrial tissue, chymase is the primary enzyme responsible for generating Angiotensin II from Angiotensin-(1-12), accounting for 65% of Ang II formation compared to only 2% by ACE.
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