Angiotensin-(1-7) Formation in the Intact Human Heart
Key result
Intracoronary enalaprilat reduced the fractional conversion of Ang-(1-7) from 0.198 to 0.06 (P<0.01), indicating its generation in the human heart depends on Ang II substrate availability.
Why the study?
Does intracoronary enalaprilat reduce the formation of Ang-(1-7) from Ang I in the intact human heart?
Population
4 heart transplantation recipients
Comparison
Intracoronary enalaprilat coadministered with… vs Intracoronary 123I-Ang I alone
Design
Case_series
Authors
Discussion
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Member takes
Implication
Intracoronary ACE inhibition suppresses cardiac Ang-(1-7) formation; leaves open clinical relevance of local pathways pending larger studies.
Structured PICO
Does intracoronary enalaprilat reduce the formation of Ang-(1-7) from Ang I in the intact human heart?
P
Population
4 heart transplantation recipients
I
Intervention
Intracoronary enalaprilat coadministered with intracoronary 123I-Ang I
C
Comparator
Intracoronary 123I-Ang I alone (baseline before enalaprilat)
O
Outcome
Fractional conversion and net production of 123I-Ang-(1-7) and 123I-Ang II across the myocardial circulationsurrogate
Main Result
Absolute Event Rate: 0.06% vs 0.198%
p-value: p=<0.01
Ang-(1-7) generation in the intact human heart is primarily dependent on the substrate availability of Ang II, as demonstrated by its significant reduction following ACE inhibition with enalaprilat.
Cite This Study
Zisman et al. (2003) studied Heart transplantation (n=4). Intracoronary enalaprilat vs. Baseline (before enalaprilat) was evaluated on Fractional conversion of 123I-Ang-(1-7) (p=<0.01). Intracoronary enalaprilat reduced the fractional conversion of Ang-(1-7) from 0.198 to 0.06 (P<0.01), indicating its generation in the human heart depends on Ang II substrate availability.