Key result
Exogenous angiotensin-(1-12) caused the rapid appearance of angiotensin I and II, and a steady rise in angiotensin-(1-7) in isolated perfused rat hearts.
Population
Isolated perfused hearts mounted on a Langendorff apparatus from three normotensive and two hypertensive rat…
Comparison
Exogenous angiotensin- added to the perfusate vs Perfusion with Krebs solution for 60 min before…
Design
Preclinical
Follow-up
60 min
Authors
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Hypothesis-generating for angiotensin-(1-12) as cardiac precursor in rats; leaves open relevance to human cardiovascular disease.
Angiotensin-(1-12) is a functional substrate for the formation of active angiotensin peptides in cardiac tissue, highlighting a novel precursor pathway in the renin-angiotensin system.
Trask et al. (2008) studied Normotensive and hypertensive rat strains. Exogenous angiotensin-(1-12) vs. Baseline (before addition) was evaluated on Generation of angiotensin I, angiotensin II, and angiotensin-(1-7). Exogenous angiotensin-(1-12) caused the rapid appearance of angiotensin I and II, and a steady rise in angiotensin-(1-7) in isolated perfused rat hearts.
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