Why the study?
What are the local electrophysiological characteristics of regional left ventricular septal hypertrophy compared to lateral LV myocardium in patients with hypertrophic obstructive cardiomyopathy?
Population
9 patients with hypertrophic obstructive cardiomyopathy and moderate to severe symptoms
Comparison
Electroanatomic voltage mapping of the left… vs Lateral LV myocardium without evidence of…
Design
Cross-sectional
Authors
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Suggests septal hypertrophy may create VT substrate in HOCM; hypothesis-generating for mapping-guided risk stratification.
What are the local electrophysiological characteristics of regional left ventricular septal hypertrophy compared to lateral LV myocardium in patients with hypertrophic obstructive cardiomyopathy?
Septal hypertrophic areas in HOCM patients exhibit marked reduction in bipolar voltage amplitude, local conduction delay, and conduction block, which may contribute to the increased incidence of ventricular tachyarrhythmias.
Schumacher et al. (2005) studied this question.
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