What does this research mean for the field?

Regional left ventricular myocardial contraction is impaired in both hypertrophied and nonhypertrophied regions, and systolic left ventricular wall asynchrony occurs in patients with hypertrophic cardiomyopathy. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to assess regional myocardial contraction in patients with hypertrophic cardiomyopathy using magnetic resonance tagging.

January 1, 1999Japanese Circulation JournalOpen Access

Regional Left Ventricular Myocardial Contraction Abnormalities and Asynchrony in Patients With Hypertrophic Cardiomyopathy Evaluated by Magnetic Resonance Spatial Modulation of Magnetization Myocardial Tagging

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Why the study?

Does magnetic resonance SPAMM myocardial tagging identify regional left ventricular myocardial contraction abnormalities and asynchrony in patients with hypertrophic cardiomyopathy compared to normal controls?

Population

20 patients with asymmetric septal hypertrophy (HCM) and 16 age-matched normal controls (total n=36)

Comparison

Magnetic resonance spatial modulation of… vs Age-matched normal controls

Design

Case-control

Authors

YMYuichiro MishiroTokushima Breast Care Clinic TOTakashi OkiSeirei Mikatabara General Hospital AÍArata ÍuchiTokushima Hospital

Discussion

Member takes

Implication

Tagging parameters may detect subclinical LV impairment in HCM; hypothesis-generating and requires prospective validation before clinical use.

Key Points

The aim is to assess regional myocardial contraction in patients with hypertrophic cardiomyopathy using magnetic resonance tagging.
Compared 20 patients with asymmetric septal hypertrophy (HCM) to 16 age-matched controls.
Measured systolic strain ratios and strain velocities across four left ventricular regions using MR SPAMM tagging.
Analyzed differences in end-diastolic wall thicknesses and LV mass index between groups.
Systolic strain ratio was significantly lower in HCM group across all walls, particularly anterior and septal regions.
Maximum systolic strain velocity was significantly lower in the HCM group for all regions.
Standard deviation for time to maximum systolic strain (deltaT) was significantly greater in the HCM group.

Structured PICO

Population

20 patients with asymmetric septal hypertrophy (HCM) and 16 age-matched normal controls (total n=36)

Intervention

Magnetic resonance spatial modulation of magnetization (SPAMM) myocardial tagging

Comparator

Age-matched normal controls

Outcome

Regional left ventricular myocardial contraction parameters including systolic strain ratio, maximum systolic strain velocity, and time from end-diastole to maximum systolic strain (deltaT)surrogate

MR SPAMM myocardial tagging demonstrates that regional LV myocardial contraction is impaired in both hypertrophied and nonhypertrophied regions, and systolic LV wall asynchrony occurs in patients with HCM.

Cite This Study

Mishiro et al. (1999) studied this question.

synapsesocial.com/papers/6a1c45b6ea84844e355faba7 https://doi.org/10.1253/jcj.63.442

Topics

Echocardiography Hypertrophic cardiomyopathy

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Implication

Tagging parameters may detect subclinical LV impairment in HCM; hypothesis-generating and requires prospective validation before clinical use.