January 1, 1989AJP Cell Physiology
SR Ca loading in cardiac muscle preparations based on rapid-cooling contractures
Population
Trabeculae from rabbit, rat, guinea pig, and frog ventricle and rabbit atrium
Comparison
Varying rest periods, stimulation frequencies… vs Steady-state stimulation or baseline conditions
Design
Preclinical
Authors
Discussion
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Implication
Species differences in rest responses require caution selecting animal models for Ca²⁺ studies; leaves open human translational relevance.
Structured PICO
P
Population
Trabeculae from rabbit, rat, guinea pig, and frog ventricle and rabbit atrium
I
Intervention
Varying rest periods, stimulation frequencies, and extracellular calcium concentrations
C
Comparator
Steady-state stimulation or baseline conditions
O
Outcome
Twitch force and rapid-cooling contracture (RCC) forcesurrogate
Mammalian cardiac muscles exhibit fundamental differences in sarcoplasmic reticulum calcium metabolism and loading during rest periods.
Cite This Study
Donald M. Bers (1989) studied this question.