Population
Guinea pig ventricular myocytes
Comparison
Rest intervals with superfusion of normal Tyrode… vs Superfusion with 0 mM Ca2+, 4 mM Ca2+, or…
Design
Preclinical
Authors
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Supports extracellular Ca2+ uptake into depleted SR during rest in guinea pig myocytes; leaves open the entry route and clinical translation.
In guinea pig ventricular myocytes, a Ca2+-depleted sarcoplasmic reticulum reaccumulates Ca2+ from the extracellular space during rest, though the exact entry route remains unclear.
Terracciano et al. (1996) studied this question.
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