What does this research mean for the field?

In guinea pig ventricular myocytes, the amount of calcium released from the sarcoplasmic reticulum declines exponentially with increasing rest intervals, which subsequently slows the time to peak of the Na+/Ca2+ exchange current. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

August 1, 1995Circulation Research

Effects of Rest Interval on the Release of Calcium From the Sarcoplasmic Reticulum in Isolated Guinea Pig Ventricular Myocytes

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Population

Isolated guinea pig ventricular myocytes loaded with the fluorescent dye indo 1

Design

Preclinical

Authors

CTCesare M. TerraccianoElectrophysiology RNRuby U NaqviUniversity of London KMKenneth T. MacLeodImperial College London

Discussion

Member takes

Implication

Rest-induced SR Ca2+ decline warrants caution extrapolating myocyte data; leaves open relevance to human HF or arrhythmias.

Structured PICO

Population

Isolated guinea pig ventricular myocytes loaded with the fluorescent dye indo 1

Intervention

Different rest intervals (2 to 120 seconds) prior to sarcoplasmic reticulum (SR) Ca2+ release induced by rapid cooling or 10 mmol/L caffeine

Outcome

Amount of Ca2+ released from the sarcoplasmic reticulum (SR) estimated by Na+/Ca2+ exchange current or rapid cooling contracturessurrogate

In isolated guinea pig ventricular myocytes, increasing rest intervals lead to an exponential decline in sarcoplasmic reticulum calcium release.

Cite This Study

Terracciano et al. (1995) studied this question.

synapsesocial.com/papers/6a1bccfc26cb5670aa9cea7e https://doi.org/10.1161/01.res.77.2.354

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Effects of Rest Interval on the Release of Calcium From the Sarcoplasmic Reticulum in Isolated Guinea Pig Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of Rest Interval on the Release of Calcium From the Sarcoplasmic Reticulum in Isolated Guinea Pig Ventricular Myocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider