What question did this study set out to answer?

September 11, 2001Circulation

Imaging Dispersion of Myocardial Repolarization, II

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Why the study?

Does ECG imaging accurately reconstruct epicardial measures of repolarization dispersion noninvasively in an experimental model?

Population

Open-chest dog model and a human torso model for generating body-surface potentials

Comparison

ECG imaging method to noninvasively reconstruct… vs Direct epicardial recordings during control…

Design

Preclinical

Authors

RGRaja N. GhanemCase Western Reserve University JBJohn E. BurnesMedtronic (United States)AWAlbert L. WaldoElectrophysiology

Discussion

Member takes

Implication

Should not yet change practice; leaves open clinical translation of ECG imaging for repolarization assessment.

Key Points

To evaluate the feasibility of using electrocardiographic imaging to noninvasively reconstruct epicardial measures of repolarization dispersion from body-surface electrical data.
Recorded epicardial potentials in an open-chest canine model using a 224-electrode sock during control, regional warming, cooling, and simultaneous adjacent warming/cooling.
Generated body-surface potentials within a human torso model, introduced realistic geometric errors and noise, and noninvasively reconstructed epicardial activation recovery intervals (ARIs) and QRST integrals.
Electrocardiographic imaging accurately captured shortened ARIs and increased QRST integrals over warmed regions, as well as prolonged ARIs and decreased QRST integrals over cooled regions.
Reconstruction successfully identified steep spatial gradients of ARIs and QRST integrals across adjacent warmed and cooled myocardial areas.

Structured PICO

Does ECG imaging accurately reconstruct epicardial measures of repolarization dispersion noninvasively in an experimental model?

Population

Open-chest dog model and a human torso model for generating body-surface potentials

Intervention

ECG imaging method to noninvasively reconstruct epicardial measures of repolarization dispersion (activation recovery intervals [ARIs] and QRST integrals)

Comparator

Direct epicardial recordings during control, regional warming, cooling, and simultaneous adjacent warming and cooling

Outcome

Accuracy of noninvasive reconstruction of epicardial measures of repolarization dispersion (ARIs and QRST integrals)surrogate

ECG imaging can accurately reconstruct epicardial repolarization properties noninvasively, potentially enabling noninvasive risk stratification for life-threatening arrhythmias.

Cite This Study

Ghanem et al. (2001) studied this question.

synapsesocial.com/papers/6a0e9fb12eca052da647a146 https://doi.org/10.1161/hc3601.094277

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Imaging Dispersion of Myocardial Repolarization, II

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Imaging Dispersion of Myocardial Repolarization, II

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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