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January 1, 1990CirculationOpen Access

Correlation between in vivo transmembrane action potential durations and activation-recovery intervals from electrograms. Effects of interventions that alter repolarization time.

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Population

12 anesthetized dogs

Comparison

Cardiac sympathetic nerve stimulation, localized… vs Control states

Design

Preclinical

Authors

CHC W HawsRLRobert L. Lux

Discussion

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Overview

ARI enables preclinical repolarization studies via unipolar electrograms; leaves open human translation.

Structured PICO

P
Population
12 anesthetized dogs
I
Intervention
Cardiac sympathetic nerve stimulation, localized epicardial warming, and graded reductions in myocardial perfusion
C
Comparator
Control states
O
Outcome
Correlation between activation-recovery interval measured from unipolar electrograms and transmembrane action potential durationsurrogate

Activation-recovery intervals from unipolar electrograms accurately reflect local transmembrane action potential durations under various physiological interventions in an in vivo canine model.

Cite This Study

Haws et al. (1990) studied this question.

synapsesocial.com/papers/6a0e9fb12eca052da647a149https://doi.org/10.1161/01.cir.81.1.281
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