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Experimental work develops Darzens reaction yielding epoxyketones in moderate yields, suggesting versatility.
Darzens condensations of 2,2,2‐trifluoroacetophenones with α‐fluoroindanones were developed. A variety of tetrasubstituted α,β‐epoxyketones were constructed using this protocol in moderate to good yields (up to 76%), with moderate to excellent diastereoselectivities (up to 94:6 dr).
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Zhao et al. (2026) studied this question.
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