Darzens Reaction of 2,2,2‐Trifluoroacetophenones With α‐Fluoroindanones

Key Points

• To develop a Darzens condensation reaction between 2,2,2-trifluoroacetophenones and α-fluoroindanones for the synthesis of epoxyketones.
• Conducted Darzens reactions of 2,2,2-trifluoroacetophenones with α-fluoroindanones.
• Synthesis yielded a variety of tetrasubstituted α,β-epoxyketones with evaluated yields and diastereoselectivities.
• Achieved moderate to good yields of epoxyketones, with a maximum yield of 76%.
• Generated products exhibited diastereoselectivities ranging up to 94:6 dr.