Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 21, 2026Journal of Cardiovascular Translational ResearchOpen Access

Iron screening occurs in only ~23% of ADHF admissions, driven by anemia rather than guidelines.

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Correction of iron deficiency with intravenous iron in HF patients may improve outcomes but is rarely assessed in real-world studies, and hospital admission presents an opportunity for identification and treatment.

What is the frequency and what are the predictors of iron deficiency screening in patients admitted with acute decompensated heart failure?

Population

2,275 patient admissions for decompensated HF

Design

Observational study

Key result

Assessment of iron status was performed in only 23.1% of 2,275 patients admitted for acute decompensated heart failure, with testing primarily driven by anemia rather than heart failure guidelines.

Authors

ASAlex M. SindledeckerYNYassar NabeelOPOlivia Palladino

Discussion

Loading...

Member takes

Overview

Infrequent iron study availability during decompensated HF admissions highlights a care gap; leaves open whether routine testing improves outcomes.

Key Points

  • To evaluate the prevalence of iron deficiency in heart failure patients admitted for decompensation and the effectiveness of treatment methods.
  • Analyzed data from 2,275 patient admissions for decompensated heart failure.
  • Conducted iron studies on 526 patients (23.1%) to identify iron deficiency.
  • Assessed associations of anemia and kidney disease with iron status availability.
  • Identified iron deficiency in 332 out of 526 patients (63.1%).
  • 132 patients (46.3%) received treatment during admission, including 241 oral and 285 intravenous cases.
  • Predictors indicate that anemia is a more significant factor for iron study availability than heart failure severity.

Study Design

Type

Observational (n=2,275)

Multicenter

No

Structured PICO

What is the frequency and what are the predictors of iron deficiency screening in patients admitted with acute decompensated heart failure?

P
Population
2,275 patient admissions for decompensated heart failure
I
Intervention
Iron deficiency screening (iron studies)
O
Outcome
Availability of iron studies

Despite guidelines, iron deficiency screening in acute heart failure remains low and is primarily driven by anemia rather than heart failure status.

Limitations

  • Retrospective review dependent on medical record accuracy
  • Inability to accurately acquire prior to admission medications
  • Oral iron use may have been under- or over-reported
  • Categorization of patients by LVEF was based on the most recent LVEF available within the prior 6 months

Cite This Study

Sindledecker et al. (2026) conducted an observational in Acute decompensated heart failure (n=2,275). Iron status assessment (ferritin and TSAT) was evaluated on Availability of iron studies within 180 days prior to or during admission. Assessment of iron status was performed in only 23.1% of 2,275 patients admitted for acute decompensated heart failure, with testing primarily driven by anemia rather than heart failure guidelines.

synapsesocial.com/papers/6a0ea188be05d6e3efb604cdhttps://doi.org/10.1007/s12265-026-10774-8
View Full Paper
Ask AI
Bookmark
Share