Iron deficiency in patients with HFpEF was associated with a significantly longer hospital length of stay compared to iron replete patients (11 vs. 9 days, p=0.036).
Observational (n=503)
No
Is iron deficiency associated with increased length of stay and worse clinical metrics in patients with acute decompensated heart failure?
Iron deficiency is highly prevalent in both HFrEF and HFpEF during acute decompensation, and is independently associated with prolonged hospital length of stay specifically in HFpEF.
Absolute Event Rate: 11% vs 9%
p-value: p=0.036
The aim of this study was to characterize iron deficiency (ID) in acutely decompensated heart failure (ADHF) and identify whether ID is associated with dyspnea class, length of stay (LOS), biomarker levels, and echocardiographic indices of diastolic function in patients with reduced ejection fraction (HFrEF) and with preserved ejection fraction (HFpEF). Consecutive patients admitted with ADHF at a single tertiary center were included. Demographic information, pathology investigations, and metrics regarding hospital stay and readmission were recorded. Patients were classified as having ‘absolute’ ID if they had a ferritin level <100 ng/mL; or ‘functional’ ID if they had a ferritin 100–200 ng/mL and a transferrin saturation <20%. Of 503 patients that were recruited, 270 (55%) had HFpEF, 160 (33%) had HFREF, and 57 (12%) had heart failure with mid-range ejection fraction. ID was present in 54% of patients with HFrEF and 56% of patients with HFpEF. In the HFpEF group, ID was associated with a LOS of 11 ± 7.7 vs. 9 ± 6 days in iron replete patients, p = 0.036, and remained an independent predictor of increased LOS in a multivariate linear regression incorporating comorbidities, age, and ID status. This study corroborates a high prevalence of ID in both HFrEF and HFpEF, and further shows that in patients with HFpEF there is a prolongation of LOS not seen in HFrEF which may indicate a more prominent role for ID in HFpEF.
Beale et al. (Tue,) conducted a observational in Acute Decompensated Heart Failure (n=503). Iron deficiency vs. Iron replete was evaluated on Length of stay (LOS) in HFpEF patients (p=0.036). Iron deficiency in patients with HFpEF was associated with a significantly longer hospital length of stay compared to iron replete patients (11 vs. 9 days, p=0.036).