Key result
Iron deficiency in HFpEF is associated with worse exercise capacity and functional outcomes, but had no impact on death or hospitalisation in 3 of 4 studies.
Why the study?
Iron deficiency has an established impact on outcomes in HFrEF, but there is a lack of conclusive evidence regarding its prevalence and impact in patients with HFpEF.
What is the prevalence of iron deficiency in HFpEF and does it impact functional outcomes, hospitalization, or mortality?
Population
Patients with HFpEF defined as heart failure with an ejection fraction ≥50%
Comparison
Iron deficiency vs no iron deficiency
Design
Systematic review and random-effects meta-analysis
Authors
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Should not prompt iron repletion to cut HFpEF death or hospitalization; leaves open functional effects.
Meta-Analysis
What is the prevalence of iron deficiency in HFpEF and does it impact functional outcomes, hospitalization, or mortality?
Iron deficiency is highly prevalent in HFpEF and is associated with worse functional outcomes and quality of life, though not with increased mortality or hospitalization.
Beale et al. (2019) conducted a meta-analysis in Heart failure with preserved ejection fraction (HFpEF). Iron deficiency vs. No iron deficiency was evaluated on Composite prevalence of iron deficiency. Iron deficiency in HFpEF is associated with worse exercise capacity and functional outcomes, but had no impact on death or hospitalisation in 3 of 4 studies.
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