Why the study?
Whether and how iron deficiency impacts patients with HFpEF remains unclear.
Does iron deficiency worsen prognosis and exercise capacity in patients with heart failure with preserved ejection fraction?
Population
300 HFpEF patients
Comparison
Iron deficiency vs no iron deficiency
Follow-up
4 years
Key result
Iron deficiency in patients with HFpEF was associated with a higher risk of combined all-cause mortality and HF hospitalization over 4 years (log rank P=0.008).
Authors
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Supports risk stratification by iron status in HFpEF; leaves open whether repletion improves outcomes.
Cohort (n=300)
Does iron deficiency worsen prognosis and exercise capacity in patients with heart failure with preserved ejection fraction?
p-value: p=0.008
In patients with HFpEF, iron deficiency is associated with a worse long-term prognosis regarding mortality and heart failure hospitalization, though its apparent impact on exercise capacity is multifactorial and confounded by comorbidities like pulmonary hypertension.
Aizpurua et al. (2021) conducted a cohort in Heart failure with preserved ejection fraction (HFpEF) (n=300). Iron deficiency vs. No iron deficiency was evaluated on Combined all-cause mortality and HF hospitalization (p=0.008). Iron deficiency in patients with HFpEF was associated with a higher risk of combined all-cause mortality and HF hospitalization over 4 years (log rank P=0.008).