Why the study?
Studies assessing the effects of iron deficiency in HFpEF are few and have included small numbers of participants.
Does iron deficiency worsen functional capacity and quality of life in patients with HFpEF?
Population
447 HFpEF patients
Comparison
Iron deficiency vs normal iron status
Design
Cross-sectional study
Key result
Iron deficiency in HFpEF patients was associated with worse 6-minute walk test distance (271 vs 310 m, p<0.01) and worse quality of life scores (49 vs 43, p=0.01) compared to normal iron status.
Authors
Loading...
Should not yet change practice in HFpEF; leaves open whether iron repletion improves functional capacity or quality of life.
Cross-Sectional (n=447)
Does iron deficiency worsen functional capacity and quality of life in patients with HFpEF?
Absolute Event Rate: 271% vs 310%
p-value: p=< 0.01
Iron deficiency is highly prevalent in HFpEF and is associated with significantly worse functional capacity and quality of life, with serum soluble transferrin receptor being a strong predictor.
Alcaide-Aldeano et al. (2020) conducted a cross-sectional in Heart failure with preserved ejection fraction (HFpEF) (n=447). Iron deficiency vs. Normal iron status was evaluated on Submaximal exercise capacity measured by the 6-min walking test (6MWT) (p=< 0.01). Iron deficiency in HFpEF patients was associated with worse 6-minute walk test distance (271 vs 310 m, p<0.01) and worse quality of life scores (49 vs 43, p=0.01) compared to normal iron status.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: