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July 18, 2026Pakistan Armed Forces Medical JournalOpen Access

Effects of Iron Deficiency Anemia on Functional Status of Patients of Heart Failure with Reduced Ejection Fraction

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Why the study?

The study was conducted to evaluate the effects of iron deficiency anaemia on the functional status of patients with heart failure with reduced ejection fraction.

Does iron deficiency anemia impair functional status and quality of life in adult patients with chronic HFrEF?

Population

320 adult patients with chronic HFrEF

Comparison

IDA vs non-IDA

Design

Analytical cross-sectional study

Key result

Iron deficiency anemia in patients with HFrEF was associated with significantly lower 6-minute walk test distance (280.98 vs. 303.32 m, p<0.001) and KCCQ scores (42.72 vs. 47.28, p<0.001).

Authors

AHAhtasham Ul HassanFSFarrukh SherASAasim Ali Sajid

Discussion

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Member takes

Overview

Should not yet change HFrEF management; cross-sectional data leaves open causal effects of iron repletion on outcomes.

Key Points

  • Evaluate the effects of iron deficiency anemia on the functional status of patients with heart failure with reduced ejection fraction.
  • Analytical cross-sectional study with 320 patients with chronic HFrEF.
  • Functional status assessed using NYHA class, 6MWT, and KCCQ.
  • Multivariable linear regression identified predictors of 6MWT distance.
  • 61.3% of patients had iron deficiency anemia (IDA).
  • Patients with IDA had significantly lower mean haemoglobin (11.17 g/dL vs 13.54 g/dL, p<0.001) and 6MWT distance (280.98 m vs 303.32 m, p<0.001).
  • Regression analysis indicated transferrin saturation (β=0.18, p=0.015) and haemoglobin (β=0.23, p=0.011) as independent predictors of 6MWT distance.

Study Design

Type

Cross-Sectional (n=320)

Multicenter

No

Structured PICO

Does iron deficiency anemia impair functional status and quality of life in adult patients with chronic HFrEF?

P
Population
320 adult patients with chronic heart failure with reduced ejection fraction.
E
Exposure
Iron deficiency anemia (defined as serum ferritin <100 µg/L or 100–299 µg/L with transferrin saturation [TSAT] <20%)
C
Comparator
No iron deficiency anemia
O
Outcome
Functional status assessed by New York Heart Association (NYHA) class, six-minute walk test (6MWT) distance, and Kansas City Cardiomyopathy Questionnaire (KCCQ) scorepatient reported

Main Result

Absolute Event Rate: 280.98% vs 303.32%

p-value: p=<0.001

Iron deficiency anemia is highly prevalent in HFrEF patients and is associated with significantly impaired functional capacity and quality of life.

Cite This Study

Hassan et al. (2026) conducted a cross-sectional in Heart failure with reduced ejection fraction (HFrEF) (n=320). Iron deficiency anemia vs. Non-iron deficiency anemia was evaluated on 6-minute walk test (6MWT) distance (p=<0.001). Iron deficiency anemia in patients with HFrEF was associated with significantly lower 6-minute walk test distance (280.98 vs. 303.32 m, p<0.001) and KCCQ scores (42.72 vs. 47.28, p<0.001).

synapsesocial.com/papers/6a5b38f68167787360d24de0https://doi.org/10.51253/pafmj.v76isuppl-7.13980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron Deficiency: Impact on Functional Capacity and Quality of Life in Heart Failure with Preserved Ejection Fraction2020 · 59 citations
  2. 2Iron deficiency in chronic heart failure with preserved ejection fraction2025 · 1 citations
  3. 3Functional Iron Deficiency in Patients With Heart Failure: A Focus on Its Prevalence Among Hospitalized Patients and Short-Term Outcomes2025
  4. 4IMPACT OF IRON DEFICIENCY ON CLINICAL,BIOCHEMICAL AND ECHOCARDIOGRAPHIC PARAMETERS IN HEART FAILURE PATIENTS2024
  5. 5Iron Deficiency: A Silent Threat in Patients With Heart Failure With Reduced Ejection Fraction2024 · 1 citations