July 1, 1994Clinical Genetics
Confounding results of Lp(a) lipoprotein measurements with some test kits
Key result
Commercially available Lp(a) test kits suffer from lack of standardization and cross-reactivity, explaining why some studies failed to detect the association between high Lp(a) and CHD.
Design
Review
Authors
Discussion
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Member takes
Implication
Current Lp(a) assays should not guide decisions; leaves open the true CHD association pending standardization.
PICO
P
Population
Coronary heart disease
I
Intervention / Comparator
Lp(a) lipoprotein test kits
Methodological issues with Lp(a) test kits, such as lack of standardization and isoform variation, may explain conflicting results regarding Lp(a) as a CHD risk factor.
Cite This Study
Kåre Berg (1994) conducted a review in Coronary heart disease. Lp(a) lipoprotein test kits was evaluated. Commercially available Lp(a) test kits suffer from lack of standardization and cross-reactivity, explaining why some studies failed to detect the association between high Lp(a) and CHD.