What question did this study set out to answer?

This systematic review aims to identify modifiable risk factors for Alzheimer's disease in Latin America from 2000 to 2024.

May 21, 2026Open Access

Modifiable Risk Factors for Alzheimer's Disease in Latin America: A Systematic Review of Epidemiological Evidence (2000-2024)

Key Points

This systematic review aims to identify modifiable risk factors for Alzheimer's disease in Latin America from 2000 to 2024.
Analyzed 63 studies focused on 12 risk factors outlined by the Lancet Commission.
Estimated population-attributable fractions for identified risk factors.
Evaluated the impact of low educational attainment and hypertension.
Found that the population-attributable fraction for the modifiable risk factors ranges from 35% to 48%.
Identified low educational attainment with an odds ratio of 1.8-3.2 as a significant risk factor.
Hypertension was also noted as a priority target with an odds ratio of 1.6-2.4.

Abstract

ZENODO INTELLIGENCE Enhanced Version Contextual enrichment for topics: educacion, latinoamerica. Research contribution in Education and Pedagogy. Research contribution on Latin American regional data. Attached files: contextual bibliography, extended multilingual abstract, methodology notes, related works index. Systematic review of modifiable risk factors for Alzheimer's disease in Latin American populations (2000-2024). Analyzes 63 studies examining 12 Lancet Commission risk factors. Combined population-attributable fraction estimates: 35-48%. Low educational attainment (OR 1.8-3.2) and hypertension (OR 1.6-2.4) are the highest-priority targets. Linked dataset: https://doi.org/10.7910/DVN/UVHABW (CC0 1.0)

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