Key result
Cystatin C-based formulas demonstrated lower bias and higher accuracy in predicting glomerular filtration rate compared to the Cockcroft-Gault formula.
Why the study?
Do cystatin C-based formulas estimate GFR more accurately than the Cockcroft-Gault formula in adult patients?
Population
451 adult patients referred to the University Hospital for determination of GFR by iohexol clearance…
Comparison
Cystatin C-based formulas to predict GFR vs Cockcroft-Gault formula for creatinine clearance
Design
Cross-sectional
Authors
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Cystatin C formulas may estimate GFR more accurately than Cockcroft-Gault; hypothesis-generating and requires prospective validation before practice change.
Observational (n=451)
No
Do cystatin C-based formulas estimate GFR more accurately than the Cockcroft-Gault formula in adult patients?
Cystatin C-based formulas provide a more accurate estimation of GFR than the traditional Cockcroft-Gault formula, without requiring anthropometric variables.
Grubb et al. (2005) conducted an observational in Patients referred for determination of glomerular filtration rate (n=451). Cystatin C-based formulas vs. Cockcroft-Gault formula was evaluated on Bias (median percent error), correlation (adjusted R2), and accuracy (percentage of estimates within 30 and 50% of iohexol clearance) in predicting GFR. Cystatin C-based formulas demonstrated lower bias and higher accuracy in predicting glomerular filtration rate compared to the Cockcroft-Gault formula.
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