What question did this study set out to answer?

To evaluate the diagnostic accuracy of cystatin C-based estimated glomerular filtration rate compared to iohexol clearance in patients with advanced renal disease and low filtration rates.

January 1, 2007Scandinavian Journal of Clinical and Laboratory Investigation

Estimated glomerular filtration rate (eGFRCystC) from serum cystatin C shows strong agreement with iohexol clearance in patients with low GFR

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Authors

AJAnn-Sofie Jonsson MFMats FlodinUppsala University LHLotta HanssonKarolinska University Hospital

Discussion

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Implication

Comparative study demonstrates strong agreement between cystatin C eGFR and iohexol clearance in advanced renal disease, suggesting a practical alternative to invasive testing.

Key Points

To evaluate the diagnostic accuracy of cystatin C-based estimated glomerular filtration rate compared to iohexol clearance in patients with advanced renal disease and low filtration rates.
Measured serum cystatin C concurrently with serum creatinine during iohexol clearance procedures in patients with clearance below 30 mL/min/1.73 m².
Calculated cystatin C-based filtration rates using the formula eGFR = 79.901 × (cystatin C)^-1.4389 and compared results against the standard and corrected MDRD equations (N=94 samples).
Cystatin C eGFR correlated strongly with measured iohexol clearance (r = 0.88), with 0% of patients exceeding a 50% discrepancy from iohexol values.
MDRD and corrected MDRD equations demonstrated lower correlation with iohexol clearance (r = 0.59) and systematic positive bias.
MDRD-derived eGFR differed by more than 50% from iohexol clearance in 44.7% of samples (42/94).

Cite This Study

Jonsson et al. (2007) studied this question.

synapsesocial.com/papers/6a735d3364cdd4095c2c280c https://doi.org/10.1080/00365510701397538

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Implication

Comparative study demonstrates strong agreement between cystatin C eGFR and iohexol clearance in advanced renal disease, suggesting a practical alternative to invasive testing.

Estimated glomerular filtration rate (eGFRCystC) from serum cystatin C shows strong agreement with iohexol clearance in patients with low GFR

Discussion

Member takes

Implication

Key Points

Cite This Study

Estimated glomerular filtration rate (eGFRCystC) from serum cystatin C shows strong agreement with iohexol clearance in patients with low GFR

Discussion

Member takes

Implication

Key Points

Cite This Study

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