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Develop and deploy MaGe (Magnifying Genomes), an integrated web-based system and relational database designed to streamline microbial genome annotation using comparative gene context and synteny.

January 8, 2006Nucleic Acids ResearchOpen Access

MaGe: a microbial genome annotation system supported by synteny results

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Authors

DVDavid VallenetCentre National de la Recherche Scientifique

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Implication

Software evaluation demonstrates effective microbial genome annotation via conserved synteny and metabolic reconstruction, highlighting enhanced collaborative curation across bacterial species.

Key Points

Develop and deploy MaGe (Magnifying Genomes), an integrated web-based system and relational database designed to streamline microbial genome annotation using comparative gene context and synteny.
Integrated automated gene coding re-annotation, conserved synteny exploration, and metabolic pathway reconstruction algorithms into a unified relational database.
Designed a collaborative, multi-user web interface linked to established external biological databases to allow manual curation and functional refinement early during genome finishing.
Successfully validated the platform through the comprehensive annotation of complete genomes from Acinetobacter baylyi ADP1, Pseudoalteromonas haloplanktis, and Frankia alni.
Facilitated functional re-annotation, curation, and comparative exploration for previously published bacterial genomes, including members of Yersinia, Bacillus, and Neisseria.

Cite This Study

David Vallenet (2006) studied this question.

synapsesocial.com/papers/6a0ea6cd218372ada647a2e4 https://doi.org/10.1093/nar/gkj406

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Implication

Software evaluation demonstrates effective microbial genome annotation via conserved synteny and metabolic reconstruction, highlighting enhanced collaborative curation across bacterial species.

MaGe: a microbial genome annotation system supported by synteny results

Discussion

Member takes

Implication

Key Points

Cite This Study

MaGe: a microbial genome annotation system supported by synteny results

Discussion

Member takes

Implication

Key Points

Cite This Study

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