Relationship Between Na + -Ca 2+ –Exchanger Protein Levels and Diastolic Function of Failing Human Myocardium
Key result
Increased Na+-Ca2+ exchanger expression in failing human hearts correlated inversely with frequency-dependent rise of diastolic force (r=-0.74; P<0.001), indicating preserved diastolic function.
Authors
Discussion
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Implication
NCX upregulation may preserve diastolic function in HF; hypothesis-generating in vitro data requiring in vivo confirmation.
Study Design
Type
Observational (n=35)
PICO
P
Population
Failing human myocardium (n=35)
I
Intervention / Comparator
Na+-Ca2+ exchanger protein levels vs Different phenotypes of failing hearts and nonfailing hearts
O
Primary Outcome
Frequency-dependent rise of diastolic force when stimulation rate was increased — r = -0.74, p=<0.001
Main Result
Effect estimate: r = -0.74
p-value: p=<0.001
Cite This Study
Hasenfuß et al. (1999) conducted an observational in Failing human myocardium (n=35). Na+-Ca2+ exchanger protein levels vs. Different phenotypes of failing hearts and nonfailing hearts was evaluated on Frequency-dependent rise of diastolic force when stimulation rate was increased (r = -0.74, p=<0.001). Increased Na+-Ca2+ exchanger expression in failing human hearts correlated inversely with frequency-dependent rise of diastolic force (r=-0.74; P<0.001), indicating preserved diastolic function.