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January 1, 1996Cardiovascular ResearchOpen Access

Cardiac Na+/Ca2+ exchange activity in patients with end-stage heart failure

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Population

Left ventricular samples from 11 patients with end-stage heart failure and 6 organ donors (normal controls)

Design

Case-control

Authors

HRHans ReineckeCross-Cutting CardiologyRSR. StuderVA Pittsburgh Healthcare SystemRVRoland VetterCharité - Universitätsmedizin Berlin

Discussion

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Implication

May limit diastolic Ca2+ overload yet promote arrhythmias in end-stage HF; leaves open NCX as therapeutic target.

Structured PICO

P
Population
Left ventricular samples from 11 patients with end-stage heart failure and 6 organ donors (normal controls)
C
Comparator
Left ventricular samples from 6 organ donors (normal controls)
O
Outcome
Na+/Ca2+-exchanger activity (assessed by Na+ gradient-induced 45Ca2+ transport) and protein expressionsurrogate

End-stage heart failure is associated with increased sarcolemmal Na+/Ca2+-exchanger activity and expression, which may limit diastolic Ca2+ overload but potentially enhance arrhythmogenesis.

Cite This Study

Reinecke et al. (1996) studied this question.

synapsesocial.com/papers/6a6f6fa7febe604dd7085ab0https://doi.org/10.1016/s0008-6363(95)00176-x

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Enhanced Na(+)-Ca2+ exchange activity in cardiomyopathic Syrian hamster.1994 · 92 citations
  2. 2Rat cardiac hypertrophy Altered sodium‐calcium exchange activity in sarcolemmal vesicles1988 · 65 citations
  3. 3Alteration of contractile function and excitation-contraction coupling in dilated cardiomyopathy.1992 · 224 citations
  4. 4Sarcolemmal Ca2+ transport activities in cardiac hypertrophy caused by pressure overload1989 · 55 citations
  5. 5Intracellular Ca transients in rat cardiac myocytes: role of Na-Ca exchange in excitation-contraction coupling1990 · 167 citations