May 1, 1998Stroke
Aspirin Use and Incident Stroke in the Cardiovascular Health Study
Key result
Frequent aspirin use was associated with an increased risk of ischemic stroke compared with nonusers (RR 1.6; 95% CI 1.2-2.2; P=0.001), as well as a 4-fold increased risk of hemorrhagic stroke.
Why the study?
Does aspirin use affect the risk of incident ischemic and hemorrhagic stroke in elderly people aged 65 years or older?
Population
5,011 elderly people aged 65 years or older participating in the Cardiovascular Health Study, mean age 72…
Comparison
Aspirin use at study entry vs Nonusers of aspirin
Design
Cohort
Follow-up
mean 4.2 years
Authors
Discussion
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Implication
Should not yet alter aspirin use in the elderly; this observational link leaves open causality and confounding.
Study Design
Type
Cohort (n=5,011)
Structured PICO
Does aspirin use affect the risk of incident ischemic and hemorrhagic stroke in elderly people aged 65 years or older?
P
Population
5,011 elderly people aged 65 years or older participating in the Cardiovascular Health Study, mean age 72 years, 58% women.
I
Intervention
Aspirin use (frequent or infrequent) at study entry
C
Comparator
Nonusers of aspirin
O
Outcome
Incident ischemic and hemorrhagic strokehard clinical
Main Result
Effect estimate: RR 1.6 (95% CI 1.2 to 2.2)
p-value: p=0.001
Limitations
- Confounding by reasons for aspirin use rather than cause and effect
Cite This Study
Kronmal et al. (1998) conducted a cohort in Incident stroke (n=5,011). Aspirin vs. Nonusers was evaluated on Incident ischemic stroke (RR 1.6, 95% CI 1.2 to 2.2, p=0.001). Frequent aspirin use was associated with an increased risk of ischemic stroke compared with nonusers (RR 1.6; 95% CI 1.2-2.2; P=0.001), as well as a 4-fold increased risk of hemorrhagic stroke.