Key result
Daily aspirin use increased the risk of kidney cancer in men (RR 6.3; 95% CI 2.2-17) and ischaemic heart disease in men (RR 1.9; 95% CI 1.1-3.1) and women (RR 1.7; 95% CI 1.1-2.7).
Why the study?
Does daily aspirin use affect the incidence of cardiovascular diseases, cancers, and other chronic diseases in an elderly cohort?
Population
13,987 residents of a Californian retirement community, including 8,881 women and 5,106 men, with a median…
Comparison
Aspirin taken daily vs Participants who did not take aspirin daily
Design
Cohort
Follow-up
6.5 years
Authors
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Warrants caution against routine aspirin for primary prevention in elderly; observational data leave open causality and require randomized confirmation.
Cohort (n=13,987)
Yes
Does daily aspirin use affect the incidence of cardiovascular diseases, cancers, and other chronic diseases in an elderly cohort?
Effect estimate: RR 6.3 (95% CI 2.2 to 17)
In an elderly cohort, daily aspirin use was unexpectedly associated with an increased risk of ischaemic heart disease and certain cancers, challenging its role in broad primary prevention.
Paganini‐Hill et al. (1989) conducted a cohort in Cardiovascular diseases, cancers, and other chronic diseases (n=13,987). Aspirin vs. Non-users was evaluated on Incidences of cardiovascular diseases, cancers, gastrointestinal bleeding, ulcers, and cataracts (RR 6.3, 95% CI 2.2 to 17). Daily aspirin use increased the risk of kidney cancer in men (RR 6.3; 95% CI 2.2-17) and ischaemic heart disease in men (RR 1.9; 95% CI 1.1-3.1) and women (RR 1.7; 95% CI 1.1-2.7).
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