Why the study?
Cardiovascular magnetic resonance has sensitivity limitations in detecting myocardial fibrosis, yet regional left ventricular fibrosis in mitral valve prolapse carries clinical risks such as ventricular arrhythmias and sudden cardiac death.
Design
Review
Key result
Histopathological studies demonstrate that mitral valve prolapse induces regionalized left ventricular fibrosis, particularly affecting the papillary muscles and inferobasal wall.
Authors
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May refine arrhythmia risk assessment in mitral valve prolapse; leaves open prospective validation before guiding interventions.
Histopathological studies provide crucial insights into the regionalized fibrotic remodeling in mitral valve prolapse, highlighting its potential role in arrhythmogenesis and guiding improvements in noninvasive imaging.
Dieterlen et al. (2023) conducted a review in Mitral valve prolapse. Histopathological studies demonstrate that mitral valve prolapse induces regionalized left ventricular fibrosis, particularly affecting the papillary muscles and inferobasal wall.