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August 1, 2022Therapeutics and Clinical Risk ManagementOpen Access

Comparison of Diagnostic Value Between STE+LDDSE and CMR-FT for Evaluating Coronary Microvascular Obstruction in Post-PCI Patients for STEMI

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Key result

Speckle tracking plus low-dose dobutamine stress echo matches CMR-FT accuracy for detecting CMVO.

  • P>0.05
  • n=61

Why the study?

Coronary microvascular obstruction is associated with poor prognosis after STEMI, but data comparing CMR-FT with STE combined with LDDSE were scarcely available.

Does STE+LDDSE provide comparable diagnostic accuracy to CMR-FT for detecting CMVO in post-PCI STEMI patients?

Comparison

CMR-FT vs STE+LDDSE vs STE alone

Design

Diagnostic comparison study

Authors

TLTao LiuCWChaofan WangJYJie Yin

Discussion

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Overview

STE+LDDSE may offer accessible CMVO detection comparable to CMR-FT post-PCI STEMI; hypothesis-generating and requires prospective validation before practice change.

Study Design

Type

Observational (n=61)

Structured PICO

Does STE+LDDSE provide comparable diagnostic accuracy to CMR-FT for detecting CMVO in post-PCI STEMI patients?

P
Population
61 STEMI patients evaluated within 5-7 days after primary percutaneous coronary intervention (PCI)
I
Intervention
Speckle tracking echocardiography (STE) combined with low-dose dobutamine stress echocardiography (LDDSE)
C
Comparator
Cardiac magnetic resonance feature tracking (CMR-FT)
O
Outcome
Detection of infarcted myocardium segments with coronary microvascular obstruction (CMVO) compared to late gadolinium-enhancement cardiac magnetic resonance imaging (LGE-CMR) gold standardsurrogate

Main Result

Absolute Event Rate: 78.7% vs 80.25%

p-value: p=>0.05

STE combined with low-dose dobutamine stress echocardiography provides comparable diagnostic accuracy to CMR-FT for detecting coronary microvascular obstruction in post-PCI STEMI patients, offering a potentially more accessible alternative.

Cite This Study

Liu et al. (2022) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=61). Speckle tracking echocardiography combined with low-dose dobutamine stress echocardiography (STE+LDDSE) vs. Cardiac magnetic resonance feature tracking (CMR-FT) was evaluated on Detection of infarcted myocardium segments with coronary microvascular obstruction (CMVO) (p=>0.05). Speckle tracking echocardiography combined with low-dose dobutamine stress echocardiography detected CMVO with similar accuracy to CMR-FT (78.70% vs 80.25%; P>0.05).

synapsesocial.com/papers/6a0ea87f53f874f2b2229bb8https://doi.org/10.2147/tcrm.s374866
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Value of 3-Dimensional Speckle Tracking Echocardiography in the Prediction of Microvascular Obstruction and Left Ventricular Remodeling in Patients With ST-Elevation Myocardial Infarction2016 · 18 citations
  2. 2L’ecocardiografia speckle tracking: roadmap per la misurazione e l’utilizzo clinico2017 · 53 citations
  3. 3Quantification of regional contractile function after infarction: strain analysis superior to wall thickening analysis in discriminating infarct from remote myocardium2001 · 183 citations
  4. 4Coronary Microvascular Obstruction — A Puzzle with Many Pieces2015 · 20 citations
  5. 5Microvascular obstruction after percutaneous coronary intervention2009 · 18 citations