July 25, 2006Journal of Cardiovascular Electrophysiology
Frequency Mapping of the Pulmonary Veins in Paroxysmal Versus Permanent Atrial Fibrillation
Key result
Paroxysmal atrial fibrillation exhibited higher frequency pulmonary vein activity than permanent AF (11.0 vs 8.8 Hz; P=0.0003) and more frequent AF termination following isolation (11/20 vs 0/14).
Why the study?
Does the contribution of pulmonary vein activity to the maintenance of atrial fibrillation differ between paroxysmal and permanent AF?
Population
34 patients with paroxysmal atrial fibrillation or permanent atrial fibrillation undergoing ablation
Comparison
Pulmonary vein isolation with frequency mapping vs Paroxysmal AF compared to permanent AF
Design
Cohort
Authors
Discussion
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Implication
May support PV-focused ablation in paroxysmal AF; leaves open type-specific strategies pending prospective trials.
Study Design
Type
Observational (n=34)
Structured PICO
Does the contribution of pulmonary vein activity to the maintenance of atrial fibrillation differ between paroxysmal and permanent AF?
P
Population
34 patients with paroxysmal atrial fibrillation (n = 20) or permanent atrial fibrillation (n = 14) undergoing ablation
I
Intervention
Pulmonary vein isolation (ablation) with frequency mapping (32 seconds of electrograms from each PV and coronary sinus prior to ablation)
C
Comparator
Paroxysmal AF compared to permanent AF
O
Outcome
Frequency of activity of each pulmonary vein and coronary sinus (defined as the highest amplitude frequency on spectral analysis)surrogate
Main Result
Absolute Event Rate: 11% vs 8.8%
p-value: p=0.0003
Pulmonary veins play a more dominant role in maintaining paroxysmal AF than permanent AF, as evidenced by higher PV frequencies and greater rates of AF termination following PV isolation in paroxysmal AF.
Cite This Study
Sanders et al. (2006) conducted an observational in Atrial fibrillation (n=34). Pulmonary vein isolation vs. Permanent atrial fibrillation was evaluated on Pulmonary vein frequency activity (Hz) (p=0.0003). Paroxysmal atrial fibrillation exhibited higher frequency pulmonary vein activity than permanent AF (11.0 vs 8.8 Hz; P=0.0003) and more frequent AF termination following isolation (11/20 vs 0/14).