Key result
Digoxin relies on renal clearance while digitoxin utilizes non-renal elimination mechanisms.
This review discusses the pharmacological properties and pharmacokinetic differences between digoxin and digitoxin in the context of heart failure management.
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May inform digitalis selection by renal function; leaves open comparative outcome trials in heart failure.
Tarabanis et al. (2026) conducted a review in Heart Failure. Digitalis glycosides (digoxin and digitoxin) was evaluated. Digitalis glycosides like digoxin and digitoxin have distinct pharmacokinetic profiles, with digoxin relying on renal clearance and digitoxin utilizing non-renal elimination mechanisms.
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