Key result
Intensive BP treatment is linked to ~29% fewer CV events alongside standard, not intensive, glycemic control.
Why the study?
Does intensive blood pressure treatment reduce cardiovascular events in patients with type 2 diabetes mellitus receiving standard versus intensive glycemic control?
Population
4,733 patients with type 2 diabetes mellitus from the ACCORD BP trial
Comparison
Intensive blood pressure treatment vs Standard blood pressure treatment
Design
Cohort
Follow-up
mean 4.5 years
Authors
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Intensive BP lowering was associated with fewer events only under standard glycemic control; leaves open interaction effect for randomized confirmation.
Observational (n=4,733)
Does intensive blood pressure treatment reduce cardiovascular events in patients with type 2 diabetes mellitus receiving standard versus intensive glycemic control?
Effect estimate: HR 0.71 (95% CI 0.56-0.90)
p-value: p=0.005
Intensive blood pressure lowering reduces cardiovascular events in patients with type 2 diabetes only if they are receiving standard, rather than intensive, glycemic control.
Tsujimoto et al. (2018) conducted an observational in Type 2 diabetes mellitus (n=4,733). Intensive blood pressure treatment vs. Standard blood pressure treatment was evaluated on Time to the first cardiovascular event (HR 0.71, 95% CI 0.56-0.90, p=0.005). Intensive blood pressure treatment reduced cardiovascular events in patients with type 2 diabetes receiving standard glycemic control (HR 0.71; 95% CI 0.56-0.90; P=0.005), but not intensive control.
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