Key result
Obesity-linked myocardial lipotoxicity promotes hypertrophy and diastolic dysfunction via cellular stress.
Obesity-associated myocardial lipotoxicity contributes to hypertrophic remodeling and diastolic dysfunction through complex molecular mechanisms including ER stress, oxidative stress, and altered autophagy.
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May inform lipotoxicity-targeted therapies for obesity-related diastolic dysfunction; leaves open clinical efficacy pending prospective trials.
Sletten et al. (2018) conducted a review in Obesity and myocardial lipotoxicity. Obesity-associated myocardial lipotoxicity contributes to hypertrophic remodeling and diastolic dysfunction via endoplasmic reticulum stress, oxidative stress, and inflammation.
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